Depression: Overdiagnosed by the Overwhelmed

(Full disclosure: Dr. Mojtabai kindly furnished a copy of his article for review. I don’t think this freebie altered my judgement but then, no one ever does.)

A new study shows that 3/5ths of those diagnosed with depression don’t have Major Depressive Disorder. Damning proof America’s mental health system is riddled with quacks, right? Actually, no. But it suggests a worrisome disconnect between those with mild depressive symptoms and those trained to treat them.

Ramin Mojtabai, MD, PHD, MPH

Ramin Mojtabai, MD, PHD, MPH

Ramin Mojtabai of the Johns Hopkins Bloomberg School of Public Health studied 5,639 adults who reported, “a doctor or other medical professional,” diagnosed them with  depression in 2009 or 2010. He found only 38.4% had met criteria for a major depressive episode in the past twelve months. Nearly three-quarters of those who did not meet criteria had been prescribed medication.

Who’s making these diagnoses? Probably primary care doctors – the people we’re most likely to talk to if we gain weight, lose energy or have trouble sleeping. In 2011, Mojtabai found 7% of all doctor visits involved a prescription for antidepressants.[i]  For his current study, he started with data collected through the United States National Survey of Drug Use and Health. While this study didn’t ask participants what type of medical professional diagnosed them, he found only 34.6% of those who hadn’t met criteria for a major depressive episode received outpatient mental health services. It’s not much of a leap to surmise primary-care doctors are responsible – especially considering  Mitchell and Vaze’s 2009 study, which found such doctors misdiagnosed depression more often than they identified it correctly.[ii]

Is it a problem if family doctors reach for a quick fix when they encounter mild-to-subclinical depression? Per the studies Mojtabai cites, there’s little evidence antidepressants help such cases. Effective treatments include a referral to counseling, advice on boosting one’s mood with diet and exercise, or watchful waiting. Instead of these, three-quarters of those with only mild depressive symptoms got a prescription.

Three possible solutions come to mind. None would be quick, easy or cheap.

"I need more training in what, now?" (photo: Adam Ciesielski © 2013)

“I need more training in what, now?” (photo: Adam Ciesielski © 2013)

1. Better training in diagnosis

If misdiagnosis is the problem, more training is the answer, right? Bear in mind, for every public health problem, the initial thought is, “Let’s get the primary care doctors on the case.”  Family doctors are expected to follow up on everything from lead exposure to trampoline safety.  Depression has to compete with every other disease in need of greater public awareness.

2. Counter-programming

Primary care doctors are barraged by pharmaceutical companies which promise quick and easy solutions, based on often-dubious research. Olfson and Marcus found antidepressant use doubled from 1996 to 2005. In the same period, the number of patients who received therapy as well as antidepressants dropped by a third.[iii]  (Essay question: Should we allow unscrupulous Big Pharma to exploit human suffering by placing profit ahead of facts and the public’s health, or should jackbooted government thugs trample free speech by placing unaccountable technocrats in charge?)

Organizations such as the American Counseling Association and the American Psychology Association should return fire with their own brochures. On the front cover: fit, attractive people of all ages and cultures beaming over the success of their non-pharmaceutical treatment. Inside: large-print bullet-points on how to differentiate the different intensities of depression, and the relative efficacy of medication, lifestyle improvements and counseling. Last page: a handy list of local therapists for referrals.

3.  A nationwide program

In his article, Mojtabai mentions the United Kingdom’s National Health Services’ “Improving Access to Psychological Therapies“. This program trained thousands in cognitive-behavioral therapies and provided general practitioners with free on-line training about depression. As a result, patients move easily from a more-accurate diagnosis to a simpler referral for help.

In the U.S., surveys show we dislike government programs and government spending, but we do like the benefits that spending on government programs brings. Per NHS data, their big-government program moved 45,000 workers off public benefits by getting them back to work. It also benefited the UK’s economy by an estimated £272,000,000 by preventing the need for more expensive treatments.  The program has been criticized for restricting the range of therapies available and providing lightly-trained staff. Even with these limitations, it has delivered a respectable (if non-astonishing) recovery rate of 42.5%.

For the next go-round:

Mojtabai’s study is enticingly exasperating; the kind that raises more questions than it answers. Tough questions for a follow-up:

1. Exactly who provides these misdiagnoses? Which specialty is most on-target, and which is most likely to misdiagnose? Master’s-level counselors, social workers and psychologists should all be assessed for accuracy.

2. Out of the patients who received outpatient mental health treatment, what percentage received counseling and which only received more meds from a psychiatrist?

3. How hard is it for a primary medical doctor in other countries to refer a client to therapy? How much resistance do clients offer, and what would help doctors address their concerns?

The 3/5ths of participants that grabbed the headlines may not have met criteria for Major Depressive Disorder, but it’s a safe bet they weren’t happy and fulfilled, either. More information for better diagnoses and more-appropriate treatments, please.

Citation:

Mojtabai R. Clinician-identified depression in community settings: concordance with structured-interview diagnoses. Psychother Psychosom. 2013;82(3):161-9. doi: 10.1159/000345968. Epub 2013 Mar 27.

© 2013 by Jonathan Miller. All Rights Reserved


[i] Mojtabai R, Olfson, M. Proportion Of Antidepressants Prescribed Without A Psychiatric Diagnosis Is Growing.  Health Aff August 2011 vol. 30 no. 8 1434-1442. doi: 10.1377/hlthaff.2010.1024

[ii] Mitchell A, Vaze A, Rao S. Clinical diagnosis of depression in primary care: a meta-analysis. Lancet 2009; 374: 609–19

[iii] Olfson M, Marcus SC. National Patterns in Antidepressant Medication Treatment. Arch Gen Psychiatry. 2009;66(8):848-856. doi:10.1001/archgenpsychiatry.2009.81.

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BAD THERAPY? A DISGRUNTLED EX-PSYCHOTHERAPY CLIENT SPEAKS HER PIECE

Valuable perspective from the client’s side. Can’t agree with everything that’s written here, but I count description of six significant ethics violation. Wish Disequilibrium1 knew how many ethical, competent therapists already follow her seven suggestions.

Disequilibrium1's Blog

In blogs and book reviews, I see reference by therapy professionals to the “disgruntled ex-client.”  I assume this label is pejorative and the classification perhaps is to warn therapists to create a strong filter when one hovers nearby.

So here’s my warning label: I’m a disgruntled ex-client.  My therapy mostly was harmful.   Before I’m tuned out, I hope some therapists may consider listening as I speak my piece, so they might find fewer like me at large.

I entered therapy hoping to broaden my social life and to confirm my suspicion that my typical family—wasn’t.  I never was in crisis.  My past persona was far too obliging and obeisant to authority, but not unlike a significant population percentage.  Pre-therapy I had friends, a job, occasional dates and was reasonably cheerful.  My total tally in treatment (I hate that word) was just under three years with different clinicians in different formats.

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Revolution: NIMH turns away from the DSM

dr-insel-2011

Thomas R. Insel, MD, director of the NIMH

Two weeks ago, National Institute of Mental Health director Thomas R. Insel, MD announced a revolution. The world’s largest mental-health research organization will no longer fund studies based solely on Diagnostic & Statistical Manual (DSM) diagnoses.  If, “NIMH will be re-orienting its research away from DSM categories,” sounds less subversive than, “Give me liberty or give me death,” pay attention.  The whole system of diagnosis may be upended.

The Golden Rule: Those with the gold make the rules.

When insurers began to require a DSM diagnosis,  the American Psychiatric Association (APA) cornered the market in mental health nosology. No other U.S. group has had the money, staff and interest to create a competing system.  Ambitious alternatives such as the Psychodynamic Diagnostic Manual settled for expanding on the existing design. The APA, which has earned an estimated 100 million dollars from the DSM, flaunts their monopoly in  DSM-5’s $133 cover price. By comparison, Thomas Pynchon’s “Against the Day”  is 112 pages longer,  1/10th the cost and exponentially better-written.

Forbes’s Matthew Herper believes DSM’s diagnostic weaknesses have led to failed drug trials, and so is one reason for Big Pharma’s shift from developing new psychiatric medications.  The NIMH’s 2013 budget totals nearly 1.5 billion dollars. Insel’s ready to spend some of that towards more valid diagnoses.

Reliability vs. Validity.

The last time the DSM was reformed, rather than revised, Robert Spitzer was chair and reliability was weak. Psychiatrists could only agree on a diagnosis  20% to 40% of the time.  Spitzer’s goal was for different assessors to reach the same diagnosis from the same facts as consistently as possible. He chaired contentious meetings of obstinate psychiatrists, and condensed the best opinions down to abstraction-free criteria of what a clinician could see and a client could report.  Reliability improved – some.

One offers valid insights into the human condition. The other is required by insurance companies.

One offers valid insights into the human condition.
The other is required by insurance companies.

Validity improved less. As the book defines Antisocial Personality Disorder, only three of seven criteria must be met for a diagnosis. It’s hard to argue this diagnosis describes an actual mental health disorder when it could fit two bad actors with nothing in common.   As Maria Konnikova points out, Spitzer’s subjective-observation-and report-only approach meant the APA bet everything on the least empirical source of data available.   While other fields of medicine have developed biological, physiological and genetic studies of physical diseases, the APA hasn’t kept up. Noted DSM critic Gary Greenberg tells a disheartening tale of how the DSM-5 committee rejected a proposed reinstatement of melancholia, in part because there was biochemical evidence it should be defined separately from depression.

RDoC: a system to break free of systems.

Also subversive and clever; an Omaha, NE punk band have named themselves "DSM-5".

Also subversive and clever; an Omaha, NE punk band have named themselves “DSM-5”.

To NIMH and many others,  the validity issue makes controversies over DSM-5’s changes as superficial and irrelevant as complaints about Bernie Madoff’s office décor.  In 2011, Insel announced the Research Domain Criteria (RDoC) project. This new approach defines disorders on multiple levels of data. Constructs such as negative affect, positive affect, cognitive processing and social-process systems would be tracked across dimensions of behavior, self-report, cells, genes and physiology.  Clients’ symptoms would be placed along a range from normal to abnormal, instead of being forced into discrete categories. If new influences on emotions and behavior are discovered, new layers of information can be incorporated into the model. Research projects involving DSM diagnoses will still be accepted, but researchers will be expected to think in broader terms than subjective assessment of symptom clusters.

Insel denies that RDoC is meant to replace the DSM-5. The NIMH is already developing “walk-across” list to align DSM and RDoC diagnoses. Given that RDoC 1.0 is probably years from public release, even critics as sharp-tongued as Allen Frances concur that the DSM is the best system of diagnosis clinicians have now.  None of that changes the existential threat to the APA’s subjective-observation-only model. If RDoC rebuilds diagnosis’ operating system and obtains  more-valid results, will insurers’ money stay with the DSM?

@ 2013 Jonathan Miller All Rights Reserved

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Hippocrates on Social Anxiety Disorder

Hippocrates of Kos (c. 460 BCE – c. 370 BCE)

Hippocrates of Kos (c. 460 BCE – c. 370 BCE)

I’m catching on that many Anxiety Disorder NOS diagnoses may be Social Phobia. To quote the Father of Medicine:

“(this man) … through bashfulness, suspicion, and timorousness, will not be seen abroad; loves darkness as life and cannot endure the light or to sit in lightsome places; his hat still in his eyes, he will neither see, nor be seen by his good will. He dare not come in company for fear he should be misused, disgraced, overshoot himself in gesture or speeches, or be sick; he thinks every man observes him.”

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Stress Management Blogging #5

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Invalidation at the Multiplex

... and invalidation won't actually toughen up your kid.

… and invalidation won’t actually toughen up your kid.

This week, I spotted ads for the upcoming After Earth at the local movie theater. Between the tensed faces of Will and Jaden Smith, the poster blurbs, “Danger is Real. Fear is a Choice.

Oh, Hollywood. So much sex. So much violence. So little psychological accuracy. Any $275-per-hour L.A. psychologist could have told you: emotions aren’t a rational choice, any more than logic is an emotional impulse. To tell people otherwise is invalidating.

Invalidation happens any time clients get the message their emotions or beliefs are flawed, wrong or unimportant. It is more than just negativity: “You failed the test,” states a fact. “Don’t tell me you studied when you bring home an F,” invalidates all of the student’s effort.

Everyone can handle a little. What kid has never heard, “You can’t be hungry, you just ate”? Repeated invalidation leaves people in doubt about their emotions and themselves. It’s associated with poor social skills in childrenself-harm in teen-agers, psychological distress in adulthood and worsened rheumatoid arthritis in sufferers of all ages.  In cognitive-behavioral therapy, it takes a delicate touch to challenge clients’ beliefs without invalidating them as people. When people hear enough repetitions of, “You put the pressure on yourself,” “Let’s hold a pity party,” or “Stop being so dramatic,” they’ll start invalidating themselves.

New, hesitant clients often say, “Maybe I should just get over it.”  They’ve absorbed the idea they can fix their emotional issues by choosing not to have them. The trouble is, emotions are like pets and children. We’re each responsible for our own, but we control them indirectly at best.  If you start by believing anxiety means you are weak and self-indulgent, you can wind up certain you are a failure when it doesn’t go away.

C’mon, Tinseltown! How about a tag line like,

“Danger is real.

Fear is a normal, healthy emotion everyone experiences.

You can manage it effectively with  mindful acceptance and self-validation.”

That would be much more accurate, and only cut ticket sales by half.

n.b.: . Steve Hein, of EQI.org has a .pdf on invalidation for parents of teen-agers here. Worth a read.

@ 2013 Jonathan Miller All Rights Reserved

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Hearts, Darkness and Chinua Achebe

The Nigerian novelist, Chinua Achebe,  died last week. Besides being, “one of the greatest writers of the 20th century,”  he was also a publisher, professor, deputy vice-president of a Nigerian political party and a stalwart champion for third-world writers. I studied under Achebe in undergrad.  In one class, he taught something invaluable for therapy practice.

Chinua_Achebe_- resized

RIP Chinua Achebe: November 16, 1930 – March 21, 2013

This day, we asked Professor Achebe about his famous critique of Joseph Conrad’s Heart of Darkness. First, we took deep breaths. The professor always spoke with quiet, measured dignity; so much so, it took courage once to tell him he was teaching next week’s book. Pulses calmed, we asked: was it fair to call Conrad’s masterwork racist? Didn’t  Kurtz’s character show it was Europeans who disgusted the author?

Gently, he explained we had missed his point entirely.

heartofdarknessAchebe told us about childhood in a Nigeria that was part of the British empire; where his schoolbooks taught the story of, “we Britons,” and the few Africans in storybooks were savages.  To him, it wasn’t the spears or loincloths that made these fictional natives sub-human.  He himself wrote a book in which tribesmen kill and eat a man, chatting casually over their meal. His point was speech. The only natives who speak aloud in Heart of Darkness, he said, are those under the ‘civilizing influence’ Conrad viewed with irony and despair.  The professor, a master of many languages, opined Conrad dehumanizes his natives because he limits them to animalistic shrieks and war whoops. At least Achebe let his cannibals talk.

In our first counseling class, we’re taught we should speak 30% of the time and listen 70%.  In session, we fight the urge to interrupt our clients and tell them how to fix their problems. A psychology professor told me in his years as a therapist, the lesson he’d re-learned the most was, “Shut up and listen.” Professor Achebe would have appreciated his effort. Clients often come to us because no one else will hear. Letting people talk can give back their humanity.

@ 2013 Jonathan Miller All Rights Reserved

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Mindfulness vs. PTSD

The Washington Post reported this week on new studies addressing Post-Traumatic Stress Disorder with mindfulness. Research has already found regular practice may help those with PTSD recover faster. New findings suggest it may do even more.

Elizabeth A. Stanley, PhD, of Georgetown University

Elizabeth A. Stanley, PhD, of Georgetown University

Elizabeth A. Stanley, Ph.D is professor of security studies at Georgetown University. She’s not a psychologist, but she ‘s among those who’ve found regular mindfulness practice significantly eased their post-traumatic symptoms.  Per the Post’s article, Stanley’s new study tracked 320 marines through simulated combat training. The results showed those schooled in mindfulness weren’t just calmer during the exercises, they also responded faster to new threats.

This is crucial, says Tom Minor, a University of California at San Diego neuroscientist who was one of the researchers. “That was one thing we worried about: ‘Are we going to take a bunch of Marines and turn them into chanting monks who couldn’t generate a stress response?’ But they didn’t get too relaxed.”

“Too relaxed,” is a fear for many traumatized people. With a constant perception of danger, it can be unnerving to think one might be lackadaisical about threats. Clinical evidence that mindfulness reduces response time can be a major selling point to the hypervigilant.

Opens with the titular Vietnam vet practicing mindfulness in a Buddhist monastery. Discuss.

In the “Baba Rum Raisin” days of the late 1960s and early 1970s, meditation was peddled as a cure for everything. Skepticism bordered on cynicism. This article cites peer-reviewed, clinically-validated studies such as  Thomas F. Minor‘s research, which indicates meditation boosts the hormones that repair stress-related damage and decreases the chemicals that cause it. It also mentions Martin M. Paulus’ work that shows mindfulness boosts activity in areas of the brain devoted to awareness and control of emotions.  The sample sizes are too small and the results need to be reproduced a few more times,  but the findings on mindfulness and PTSD have started to verge on Maharishi-esque territory.

Of all the goodies in the Post article, the most tantalizing (and least empirically-supported) is the suggestion that mindfulness practice may reduce the risk of developing post-traumatic symptoms:

(Marine medic Del) Cochran says he believes meditation helped him stay much calmer during his second tour in Iraq. “The first tour, I was freaked out all the time,” he says. “There was so much static. With meditation, you’re much more in tune — what is a target, what is not a target. You are much more focused on what you are doing.”

Meta-analyses of studies of traumatized children shows pre-existing anxiety may increase one’s vulnerability to PTSD. Who wants to fund a study comparing PTSD rates among veterans from countries with a cultural tradition of mindfulness practice and those without?

Citations:

Kohn, David (2013, February 18) Mindfulness and meditation training could ease PTSD symptoms, researchers say. The Washington Post. Retrieved on February 22, 2013.

Examining the protective effects of mindfulness training on working memory capacity and affective experience. By Jha, Amishi P.; Stanley, Elizabeth A.; Kiyonaga, Anastasia; Wong, Ling; Gelfand, Lois
Emotion, Vol 10(1), Feb 2010, 54-64.
 

@ 2013 Jonathan Miller All Rights Reserved

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Grief: Stages, Waves and Tasks

Clare Bidwell Smith has written a worthy essay on grief and anxiety, one that challenges Elizabeth Kübler-Ross‘s ‘bargaining’ stage:

Many of my clients immediately begin to assess their current state in terms of where they are with denial, anger, bargaining, depression, and acceptance. But while the stages were meant to be helpful, this is often where people begin to get confused. I don’t think I’m following the stages correctly, they’ll admit in a worried tone.

I don’t understand the bargaining part. I’ve been depressed for too long. I skipped the anger stage—is that okay? I don’t know where my anxiety fits in. These are the kinds of things I hear over and over again. In fact, I’ve heard them so often that I’ve now come to believe that when the five stages are applied to grief, bargaining should be replaced with anxiety.

Contemplating © 2013 by Anders Engelbøl

Not every mourner gets a soothing vista to grieve by.

Smith deserves kudos for drawing attention to anxiety’s role in grief. The loss of a loved one is a hole in our safety net. It reminds us of our own mortality. How does one not feel anxious about that? Her suggestion we make anxiety a stage of grief, on the other hand, propagates long-standing problems with the model.

For all of its cultural dominance, Kübler-Ross’s magnum opus has taken heavy fire. Bonnano, Wortman, et al (1)  found grief might take five different paths, including one of resilient recovery.  Maciejewski, Zhang et al (2) found symptoms of grief such as yearning, anger and depression rose and fell along overlapping curves, while acceptance rose along a steady upward slope.  Kübler-Ross herself freely admitted not everyone will experience each stage, the stages may not come in order, and that stages might recur once they’ve faded.  So, why describe grief in such terms?

A figure from Maciejewski and Zhang's research. While each psychological response peaks about a month apart, they all begin within three weeks of the loss and remain present throughout the process.

A figure from Maciejewski and Zhang’s research. While the first four ‘stages’ peak about a month apart, all begin within three weeks of the loss and continue nearly to the end. (see complete figure at the link)

James William Worden’s ‘task’ model drops the view of grief as a commuter ride on the Dysphoria Local.  Worden, professor at Biola University’s Rosemead School of Psychology, frames mourning as a set of chores:

  1. Accept the reality of the loss. Completely.
  2. Work through all of the emotions tied to the loss. All of them.
  3. Make all the adjustments needed to function without that person – inside and out.
  4. Find a way to maintain a link to the loved one, while you move on with your life.

Each task can be worked on a bit at a time. They don’t need to be completed in order. Anxiety, yearning, anger, depression? Each fits each task. No one needs to wonder why they still feel angry after being depressed for so long.  Worden’s model empowers our clients, because it makes grief a mission to complete, not a storm to be weathered.

The flaw in Smith’s plan to substitute ‘anxiety’ for ‘bargaining’ is the same that undermines Kübler-Ross’ model.  Symptoms like anger and anxiety rise and fall, but they don’t come in stages. They pervade the process. Let’s reassure our clients the loss of a loved one can be terrifying. Let’s not shoehorn that anxiety into an misfired concept like ‘stage’.

Citations:

1: Resilience to loss and chronic grief: A prospective study from preloss to 18-months postloss. Bonanno, George A.; Wortman, Camille B.; Lehman, Darrin R.; Tweed, Roger G.; Haring, Michelle; Sonnega, John; Carr, Deborah; Nesse, Randolph M. Journal of Personality and Social Psychology, Vol 83(5), Nov 2002, 1150-1164. doi: 10.1037/0022-3514.83.5.1150

2: Maciejewski PK, Zhang B, Block SD, Prigerson HG. An Empirical Examination of the Stage Theory of Grief. JAMA. 2007;297(7):716-723. doi:10.1001/jama.297.7.716.

@ 2013 Jonathan Miller All Rights Reserved

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Diluted DBT Still Effective for Bipolar Disorder

University of Washington psychologist Marsha Linehan has a strict definition of her ground-breaking Dialectical Behavioral Therapy (DBT). If a client doesn’t …

  • attend a DBT skills group and …
  • receive individual therapy from a DBT-trained therapist …
  • who attends a weekly DBT consultation group and …
  • offers phone coaching,

… they aren’t really in DBT. The full program is what she researched; she won’t vouch for anything less.  A new study by Van Dijk, Jeffrey and Katz of the Southlake Regional Health Centre in Ontario, Canada suggests even a cherry-picked form of ‘adherent’ DBT may still help those with Bipolar Disorder.

T-shirts like this are why I love the internet

T-shirts like this are why I love the internet

The researchers enrolled twenty-six adults with Bipolar I or II Disorder in a psychoeducational group. The clients learned about their diagnosis, but were also trained in mindfulness practice and DBT’s emotional-regulation, interpersonal-effectiveness and distress-tolerance skills. After twelve weeks of ninety-minute group sessions, the clients scored higher on Beck Depression Inventory, reported greater awareness of their emotional states and less fear of the same. Six months later, they also had fewer emergency-room visits and hospitalizations. These findings echo other studies that found DBT skills group training – by itself – can be effective for depressive symptoms.

It’s tempting and dangerous to conclude DBT can be treated like a toolbox, instead of a unified whole.  Tempting, because DBT is a comprehensive therapy for challenging clients. That makes it dauntingly complex. Becoming fully versed is like learning another language. With all of its’ useful techniques, attitudes and approaches, it’s almost too simple to cherry-pick a few and call it DBT.

It’s dangerous because Linehan’s therapy depends so much on movement, speed and flow – rapidly shifting around all of those techniques, attitudes and approaches to meet a client’s needs.  Practitioners’ mailing lists often feature tales of clients firmly uninterested in DBT because of their previous experience – with non-adherent therapists whose treatment had some of the features, but none of the integrity of Linehan’s.

Carl Rogers’ use of reflective listening and Alfred Adler’s focus on the here-and-now were subsumed into the basic practice of therapy. Linehan’s DBT skills could be mindlessly assimilated the same way. Let’s have more research on how much and how little can be dropped before you no longer have an effective therapy.

Citation:

Sheri Van Dijk, Janet Jeffrey, Mark R. Katz. A randomized, controlled, pilot study of dialectical behavior therapy skills in a psychoeducational group for individuals with bipolar disorder. Journal of Affective Disorders 5 March 2013 (volume 145 issue 3 Pages 386-393 DOI: 10.1016/j.jad.2012.05.054)

@ 2013 Jonathan Miller All Rights Reserved

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